If you are a geneticist, you would know genetic correlates. The only causality of AD that I assert is with lifestyle factors and genetic factors, e.g. APOE4, that govern neuroinflammation, as is strongly established.
APOE4 homozygozity represents a distinct genetic form of Alzheimer's disease (PMID: 38710950)
> The study concludes that APOE4 homozygotes represent a genetic form of AD
Healthy lifestyle and the risk of Alzheimer dementia (PMC7455318)
> Compared to participants with 0 to 1 healthy lifestyle factor, the risk of Alzheimer dementia was 37% lower (pooled HR 0.63, 95% CI 0.47–0.84) in those with 2 to 3 healthy lifestyle factors and 60% lower (pooled HR 0.40, 95% CI 0.28–0.56) in those with 4 to 5 healthy lifestyle factors.
With regard to lifestyle factors, here is some evidence to get you started:
Healthy lifestyle and the risk of Alzheimer dementia (PMC7455318)
> Compared to participants with 0 to 1 healthy lifestyle factor, the risk of Alzheimer dementia was 37% lower (pooled HR 0.63, 95% CI 0.47–0.84) in those with 2 to 3 healthy lifestyle factors and 60% lower (pooled HR 0.40, 95% CI 0.28–0.56) in those with 4 to 5 healthy lifestyle factors.
