Heavy emphasis on "sort of"; it enforces data types on columns, which is a significant difference from both spreadsheets and pysheets. This enables/requires more database-like behavior and planning (which is great for a lot of applications), but importing spreadsheets is much less intuitive and spreadsheet competence won't get you very far.
Grist's closer to "what if Access had an interface that was more like Excel". Pysheets is more like "what if Python data structures had a GUI that looked like Excel".
To put it another way, I love Grist but _would not_ recommend people who are using spreadsheets to try to bring their spreadsheets into it. I also love pysheets and _would_ recommend it for that usage.
https://www.getgrist.com/product/self-managed