You'd basically get Boa Constructor[0][1] and the fact that it mentions that it is based on "wxWindows"[2] and the last release was in 2007 is probably a good indicator of how much Python developers would be interested in such a program.
(incidentally there was also Visual Tcl[3] which was quite interesting in that while it had a Delphi/Lazarus/BoaConstructor-like interface, you could modify the program while it was running)
Not shipping Electron all over the place would be a reason, followed by games, 3D API that can take full advantage of the graphics card, and air gaped environments.
Huh, then why do you talk about Python? The whole point of an IDE like Delphi is the RAD tooling for GUI apps. If you don't want that, language doesn't matter.
The same topic with VB6 and putting Perl instead.