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> I wonder if people really would ossify after hundreds of years or eventually learn to be hyper-adaptable.

I'm kind of fond of Vernor Vinge's take in Rainbows End: people who undergo rejuvenation therapy go back to high school to learn a trade in the modern world. Part of the justification for this is if their brain is restored from a condition like severe dementia, they may have different personality traits and interests from their original selves, which will take time and learning to acclimate to.




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