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Yes, Nick Lane has done a great job of popularizing the metabolism first hypothesis of origin of life. What his books and videos don't address is the biggest problem of metabolism first - once there's a proto cell (say inside a pore within a white smoker) with working metabolism that turns H2 and CO2 gases into sugars and other organic molecules - how are the proteins that make the metabolism work translated and encoded into an RNA code.



His book The Vital Question does actually address this. He says the RNA world hypothesis doesn't perfectly explain early catalysis, as RNA is a sophisticated polymer. It was most likely more simple things like metal sulphides or other inorganic complexes were primarily responsible. Amino acids and nucleotides also have catalytic activity.




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