Have you tried Noita[1]? It's a Finnish 2D roguelike game inspired by Liero. Has permadeath and is generally pretty difficult but in a good way.
You play as a witch, there are wands and spells that you can put in them to make unique builds with sophisticated wand mechanics. Every pixel in the world is simulated, like in falling sand games.
It doesn't have perma death but if playing in a multiple game it can be faked.
I need to boot it up again. So far I haven't seen anything close to it, even Torchlight I.