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- Tirzepatide may activate brown fat, which might be a metabolic advantage.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396640/

- Another study - there was a 16% weight loss for those that received semaglutide/diet/exercise/counseling versus a loss of 5% for placebo those that received diet/exercise/counseling without semaglutide.

But they didn't control for calories, so it may just be proving that dietary adherence with the medication is better than without.

https://pubmed.ncbi.nlm.nih.gov/33625476/

https://classic.clinicaltrials.gov/ct2/show/NCT03611582




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