Japan has a regulatory agency, the PMDA, and you have to submit CDISC data from your trial to them to get anything approved. I’m not sure about the specifics of your question though.
So far. I'm sure someone is going to figure out how to engineer viable tooth buds for adults.
And as for "just for children" ... I had no idea how significant pediatric dental specialties were until my daughter fell out of a pickup truck onto the curb broke her two front teeth at the age of 3. Luckily her adult teeth grew in appropriately, but she still needs braces to fix the spacing in her smile that the injury left. It's been over a decade and I still feel terrible.
Sorry to hear about what happened to your daughter.
I read a really terrible story years ago, a daughter was sunbathing in the driveway on a lounger, father comes home and parks... on his daughter, who is then paralyzed.
Certainly did not mean to imply that this would be insignificant due to being “just for children”! I should have said “exclusively for children” perhaps? Just wasn’t sure if adults have tooth buds!
I’ve always wondered about this. If you’re going to pull out all the teeth from a 15-year-old, presumably they’re mostly reasonably healthy. Why not make the denture out of the person’s original teeth?
And it should be illegal imo. When i was 22 and had one done the dentist failed to inform me of any of the risks of it failing (which tends to happen in 10-20 years), and i didn't appreciate how dangerous a failure of a root canal could be.
After getting a jaw infection which quickly lead to near fatal heart issues, and then a subsequent 6 in total surgeries to remove the infection, prepare a new post and have the tooth installed, over 3 years...i wish i either had no tooth there or went straight to the post the first time around. They're barely even the cheaper alternative to a post too, it's insane to me that anyone would prefer a root canal.
Root canals are taxidermy, we shouldn't do them. And no, i'm not part of this weird science ignoring cult of people that thinks all dental treatments give us low energy or destroy our manhood (https://www.todaysrdh.com/root-cause-netflix-documentary-let...) but I do think theres superior treatment and we should use it.
Get a post/implant put in. Lasts way longer (for your lifetime if you're careful with it), and if part of it does get damaged, chances are it can be repaired.
Well, I had only root canal treatments and luckily with no jaw or heart infections yet, but I have heard of serious issues from people who got implants. The skill of the dentist matters a lot I think.
How old are your root canals? The issue is the tooth is an organic component and it doesn’t last forever when it’s no longer supplied with blood. Once it becomes brittle, and cracks, the only solution is to remove it.
Yes, they likely will not hold till I am old, but till then they are working and it was less invasive, than an implant. So one day I likely will have implants, or if I am lucky, I might skip that and just regrow a tooth, if this tech will advance. In any case, the tech will be better in the future (unless worse stuff happens).
Yeah that sounds about right. I just wish i went right to the implant personally. The risks associated with it breaking, combined with the cost of essentially doing it twice...it all feels so pointless now.
As far as I know body hair isn’t really important for your overall health, whereas teeth (and oral health in general) are extremely important. It would surprise me if we ended up being able to regrow teeth before having a non-surgical baldness remedy given how much people spend on getting their hair back, but I wouldn’t be disappointed.
I should have started maintaining a list of these 25 years ago, there would have been at least a dozen of projects intending to eliminate the tooth decay problem. Needless to say neither of them reached production.
This is amazing. Not interested in growing vampire teeth - but the ability to regrow teeth when lost - or get a new set of chompers without coffee stains sounds super cool :)
Ozempic is a lower dose of semaglutide for type-2 diabetes only. The higher maintenance dose (2.4 mg) marketed as Wegovy is for weight loss.
A weight loss oral medication will be available within a year or so, and it will dramatically reduce manufacturing costs. (The autoinjectors are very well designed and nearly painless, but they're very expensive and the whole thing is disposable.) It will still probably require a cold chain. Rybelsus is already available for diabetes but it isn't approved for weight loss in 3 7, and 14 mg doses. Novo Nordisk will likely issue an 50 mg per day for maintenance dose.
IANAD: If one can, they should first try to limit portion size because the risk of thyroid cancers with long-term semaglutide use is unknown and nonzero. There's a real possibility of another Vioxx/Fen-Phen moment.
My teeth regrow. I've mostly kept it a secret to myself because people disbelieve me. Good to know there's evidence it can be done now, I feel vindicated.
I've had cavities disappear, and teeth recover. I've had before and after x-rays side by side taken by shocked dentists. It's not to hard to believe, children teeth grow.
In all seriousness, if you have the patience and glasnost you should reach out to a scientist or related professional who can document this behaviour via bloods, x-rays, genomics or other means.
I study oral history and you’d be surprised what mundane information amazes people 50 years after the fact. Regrowing teeth would definitely fall into such a category, even if the evidence is unintelligible to present day dentists or you want aspects embargoed.
Is this only for missing teeths, or can they also use this for grown ups cavity stuff? Last time i got a cavity drilled out and filled was some like a decade ago it was annoying as fuck.
Thanks for pointing this out — I actually assumed the linked article was a different one[1] which implied that the third set could replace dentures:
> When treatment of teeth is no longer possible due to severe cavities or erosion of the dental sockets, known as pyorrhea, people lose them and need to rely on dental appliances such as dentures. The ability to grow third-generation teeth could change that. "In any case, we're hoping to see a time when tooth-regrowth medicine is a third choice alongside dentures and implants," Takahashi said.
Not related to the post, I recently read Japan not just good at automobiles and electronics, but also with pharmaceuticals and bio tech. What are some major pharmaceutical and bio tech companies in Japan?
With this approach dentistry can finally move away from being basically a glorified tooth repair shop, and usher in the 21st century with modern approaches.
Let's hope they don't migrate whatever made you decide to get a new brain though. It'd suck if they also migrated mental illnesses and old traumas and stuff.
"Would you like to try the digestive tract remapping first? It's a lot less invasive, but, if it doesn't work you'll be depressed the entire time you're making a mess of yourself."
If it works, the founder will probably become richer than your average successful startup founders because the market is huge:
Who isn't dreading going to the doctor to get an implant after having to habe a tooth removed. Now you could just regrow that tooth.