I imagine avoiding control key sequences is part of the reason why Apple added the apple/command key to their keyboards. Makes it easy to copy text in a terminal emulator, etc.!
Whenever I use Windows my fingers are surprised to remember that the windows key isn't used for menu commands.
I've been told that IBM and Microsoft though that sending application commands with dedicated key sequences wouldn't be useful. Function keys should suffice (so I think Midnight/Total Commander interfaces are the right one to expect) but later IBM came with CUDA…
Whenever I use Windows my fingers are surprised to remember that the windows key isn't used for menu commands.