The Sacklers got incredibly rich by taking tons of money out of Pursue Pharmaceutical while it was engaged in what it has admitted were criminal acts which resulted in the deaths of at least thousands. Many people view that as profiting from crime and what is worse causing widespread undeniable harm among the users of their products.
One could consider this as just very smart business though if you do not care about the people harmed. They ran a company that did bad things that allowed them to get rich but they were smart enough to keep enough distance from the bad things to ensure they themselves had deniability.
"Purdue has twice pleaded guilty to criminal charges, but no members of the Sackler family have been charged with crimes."
https://www.pbs.org/newshour/nation/after-years-of-pain-opio...