$10M/ year seems unusually high, even for med schools - are you sure those are annualized costs? Perhaps it's because I'm familiar with the more basic science (non clinical trial) parts of NIH, but a typical R01 is $250K-$500K/ year in direct costs so that would imply having to hold ~15 of them (with overheard) to reach $10M/year.
It seems like $10M in total value of active grants in a given year (~5 R01s) might be more typical (though the standard for tenure I've heard of in med schools is maybe ~2-3 R01s, so 5 would make you top tier and highly sought after).
For clarity, when I'm referring to $1M/year in annual funding, that's coming from ~6-7 active grants whose total value might be in the $5M range total.
R01s are too small to be worth applying for, typically. Or rather, most PIs have an R01 that pays for themselves and maybe some travel and publication feeds. Most of these people end up making center grants or finding other mechanisms (like non-NIH funding, such as CZI).
There's no way I personally would have been able to manage 5-6 active R01s a year; but then, when I did grant review, I noticed that other folks did a lot of copy/pasting and exagerating about their publications significance, which is not something I was willing to do.
It seems like $10M in total value of active grants in a given year (~5 R01s) might be more typical (though the standard for tenure I've heard of in med schools is maybe ~2-3 R01s, so 5 would make you top tier and highly sought after).
For clarity, when I'm referring to $1M/year in annual funding, that's coming from ~6-7 active grants whose total value might be in the $5M range total.