Part of the thing with SF is that it's somewhat unusual in that a business traveler attending an event at the Moscone is at more or less ground zero for some of the seedier parts of town: the Tenderloin, Civic Center, generally W/SW of the Moscone.
(This probably used to be somewhat true of the Javits in NYC but that whole area of the city has generally gentrified with the Hudson Yards project being the latest big change.)
(This probably used to be somewhat true of the Javits in NYC but that whole area of the city has generally gentrified with the Hudson Yards project being the latest big change.)