You can already play many local files in formats like mp4 directly in Edge or Chrome to get Nvidia VSR working, probably works with the new Edge VSR too.
If you want a media player that does this and have a 30 or 40 series Nvidia card, you can use the below custom renderer being actively developed, which uses Nvidia VSR tech with a custom renderer for Media Player Classic.
If you want a media player that does this and have a 30 or 40 series Nvidia card, you can use the below custom renderer being actively developed, which uses Nvidia VSR tech with a custom renderer for Media Player Classic.
https://github.com/emoose/VideoRenderer
People have also been using MadVR to upscale videos which uses a similar renderer but I think it doesn't have GPU limitations.