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Does anyone know of references that address how effective specific amounts of caffeine are at different times of day? This seems like the kind of question that a military would wish to study but I haven’t ever found a ‘user’s guide’ for optimal coffee use



Huberman podcast episode on caffeine.


I would be surprised if such a generalization is useful, since metabolism varies and is integral to the effects.


I suspect it will be - most of medicine uses the idea of 'reference ranges' to establish normal physiological state.

The reference range is simply the range of observed states of whatever characteristic is being measured. Here, I would be interested in a study that maps caffeine doses to changes in various characteristics such as alertness/acuity and latency between periods of falling asleep.




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