> Among outpatients with mild to moderate COVID-19, treatment with ivermectin, with a maximum targeted dose of 600 μg/kg daily for 6 days, compared with placebo did not improve time to recovery. These findings do not support the use of ivermectin in patients with mild to moderate COVID-19.
What was surprising was how quiet L arginine's benefit to help fighting covid was kept, even after a study [1]
Ivermectin was said to need only approximately 100 times the normal dose per kilo to affect the covid virus ... a Canadian hospital would later calculate and publish their findings, that the application of a human version they used, it would only require roughly 55 times the normal rate to reach the required saturation rate.
Injectable Ivermectin was very much a big part of cheap heartworm treatment in dogs around my locale back in the late 80s. There was an awareness that for some dogs it did not agree with them in the least, some fatally. For a start some cause was directed to a miscalculation on the part of the person applying it. Slowly due to overdoses, it was clear even at normal rates some dogs did not cope well. (Having witnessed first hand the effects of using way too much - at a mere 6 times more dose per kilo, all the affected dogs developed the staggers and preferred to rest, clearly dopey and not at all listful.) Humans might do better with the blood brain barrier membrane, but given the similarities I doubt no test would be ever be approved to see if an otherwise healthy person could endure 25 times normal dosage.
Presently long covid is another new problem of the pandemic - and once more L arginine might be useful. [2]
Oh, for a second I thought maybe they'd used it and I checked the articles to see if they used any panadol.
So your reply is not quite the LD50 argument but close enough. Yup water too, along with salt, very necessary and functional, but too much kills you.
How well an introduced chemical is tolerated or not, and a dosing regime comparison to other chemicals based on its LD50 does not help the discussion or further prove it might work.
Here is a simple thing to mull over:
Some genius person with an idea:- Ivermectin at 100 times the normal dose for livestock per kg kills target in a petri dish, so maybe very low dose, might do something. Best of all it's cheap and available, and if there's enough of a push, mere workers will not tie up government budget, if it doesn't work, meh ... shareholders need their dividends ...
Certain people:- Hooray no budget blowout, lets keep doing this.
People who use Ivermectin in livestock:- If Ivermectin is such a great help, who do the cattle that receive monthly injections of Ivermectin, prone to the same viruses as if they were not, not slightly better, none. After all many of those viruses also die in a petri dish with Ivermectin.
Certain people:- Hey go away you'll scare everyone.
A low dose of L arginine though can be achieved with a good diet ... but the lower income people generally don't have the best diet.
> Conclusions Among outpatients with mild to moderate COVID-19, treatment with ivermectin, with a maximum targeted dose of 600 μg/kg daily for 6 days, compared with placebo did not improve time to recovery. These findings do not support the use of ivermectin in patients with mild to moderate COVID-19.
Actually, this is a flawed conclusion. A placebo, by definition, can have an effect. Therefore, no treatment at all - which they had no control for - is not the same as getting a placebo.
Ivermectin and placebo might be about equal, but that doesn't mean no treatment at is just as good.
> Among outpatients with mild to moderate COVID-19, treatment with ivermectin, with a maximum targeted dose of 600 μg/kg daily for 6 days, compared with placebo did not improve time to recovery. These findings do not support the use of ivermectin in patients with mild to moderate COVID-19.