I'm not sure which kind of limitations you are referring to. In my experience the only kind of things I cannot replicate with TeXmacs are variable width paragraphs to follows an arbitrary shape around an image. TeXmacs can do multi-column paragraphs, and complex layouts like this one: https://github.com/texmacs/tm-forge/tree/main/examples/resum... or this one https://github.com/texmacs/tm-forge/blob/main/examples/exerc... or rich presentations like this one https://github.com/texmacs/tm-forge/blob/main/examples/lectu... One should bear in mind that TeX by itself is a Turing-complete typesetting language while TeXmacs format is a format that is it restrict the range of documents one can express in order to be able to transform them more reliably, e.g. by conversion to HTML or PDF or even LaTeX. So certainly there are many more things you can to with TeX (but not with LaTeX itself) than with TeXmacs but this is a feature, not a bug :) (very much like the fact that you can do many more things with PS than with PDF, and that is why the first is a language while the second is a format).
