Covid – Oxford/AstraZeneca Nasal Spray Vaccine Poor Trial Results

Trouble_007 · on Oct 11, 2022

Tolerability and immunogenicity of an intranasally-administered adenovirus-vectored COVID-19 vaccine

An open-label partially-randomised ascending dose phase I trial : https://www.thelancet.com/journals/ebiom/article/PIIS2352-39...

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ggm · on Oct 11, 2022

But not all nasal vaccines: just this one. As the article says, they need to try a reformulation to try and make it "stick" to nasal mucosa and not get swallowed. Or, move to an asthma inhaler type model.

Trouble_007 · on Oct 11, 2022

>But not all nasal vaccines< -- True!

Perhaps a two stage nasal inoculation is required, maybe one squirt of vaccine, plus mucous membrane penetrator,

followed by a second squirt of vaccine, plus mucous membrane sealer.

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