"Natural materials", eh? You could make the case out of wood, and insulate your wires with sap, but I'm afraid I can't think of a good natural source of n- and p-type doped silicon wafers.
Seriously though, modern semiconductor processing involves an awful lot of very nasty chemicals, you can't make a chip without 'em.
Seriously though, modern semiconductor processing involves an awful lot of very nasty chemicals, you can't make a chip without 'em.