How would the fda go about testing the convergent effects of all the different chemicals when the ratios shift significantly and the means of consuming them change what actual chemicals reach which parts of the body? Distill/synthesize each one, mix them in every permutation, and dose representative patients in every possible way?
By applying the boot to your neck, overdoses are reduced by 50%. Getting an accredited healthcare professional to tell you the boot is good for you reduces it a further 25%.
They would study a single consumption method as a solution for a specific ailment. All side effects would be documented and told to researchers or consumers.