> And it doesn't make a lot of sense that the different vaccines would be substantially different against different variants or would wane quicker once the same level of vaccination was reached. Once you've got the T-cells and B-cells they're permanent and they aren't going to remember what kind of vaccine they came from. The differences in the vaccines should just be in overall effectiveness.
Not quite. Subunit (Novavax) or inactivated virus vaccines (like the Chinese ones) do not cause synthesis of viral proteins, so they do not stimulate killer T cell immunity [1]. That's a whole arm of the immune system which is not getting primed.
[1] Except to a limited extent via cross-presentation, i know
The dendritic cells which take up the inactivated virus vaccine will chop up the structural and spike proteins and display that on host MHC for T-cells and B-cells in germinal centers. The T-cells don't know if the protein fragments come from foreign particles or cell synthesis. The happens in both mRNA vaccines and inactivated virus vaccines and both require cross-presentation by the dendritic cells.
Not quite. Subunit (Novavax) or inactivated virus vaccines (like the Chinese ones) do not cause synthesis of viral proteins, so they do not stimulate killer T cell immunity [1]. That's a whole arm of the immune system which is not getting primed.
[1] Except to a limited extent via cross-presentation, i know