I'm not sure how you're parsing out those 100k people that wouldn't have died had we had vaccines earlier since we can't get tens of millions of people to take the live-saving free vaccines that have been available for nearly a year now.
Challenge trials are fine but were hardly needed when we had unchecked spread of Covid for bog-standard RCTs. The historic speed that the vaccines made it through FDA approval were in large part due to the millions of active infections all over the country and world such that you could see the control vs. experimental groups very easily.
Challenge trials are fine but were hardly needed when we had unchecked spread of Covid for bog-standard RCTs. The historic speed that the vaccines made it through FDA approval were in large part due to the millions of active infections all over the country and world such that you could see the control vs. experimental groups very easily.