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fnord77
on Oct 28, 2021
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Cheap antidepressant shows promise treating early ...
my AD/immune system anecdote: I have an autoimmune disease. Some ADs make the disease flare up. Some (particularly tricyclics) improve the disease's symptoms.
ogwh
on Oct 28, 2021
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Tricyclics (and tetracyclics) tend to be incredibly potent antihistamines, which may explain this.
fnord77
on Oct 28, 2021
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I just looked and desipramine has a Ki of 60 for H1, which makes it sort of a weak antihistamine.
Tricyclics are TNF-alpha inhibitors. I believe that's the MOA in my case.
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