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Aren’t many SSRIs antihistaminergic?



No SSRI's are antihistaminergic. It is right in the name. SSRI only inhibit serotonin reuptake. Many antipsychotics have histamine receptor inhibition, but there are no antidepressants that block the histamine receptors.


Many antidepressants are (e.g. Mirtazapine), but not Sertraline (Zoloft).


And some old antihistamines were SSRIs.




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