On: Intestinal drug shown to boost memory and cognition

[vijay_nair]

When drugs targeting the gut have effects in the brain, serotonin receptors are usually involved and it's 5-HT4 this time. Taking carbidopa (or benserazide, another peripheral decarboxylase inhibitor) along with prucalopride can potentially enhance the memory effects by preventing gut metabolism.

Blocking 5-HT6 also improves memory (in mice) but it seems to come with circadian disruption.

[float4 → vijay_nair]

> Blocking 5-HT6 also improves memory (in mice) but it seems to come with circadian disruption.

So the memory improvement is temporary then I reckon? Because my guess would be that circadian disruption -> poor sleep -> poor memory.

Edit: also, any books you can recommend on this topic? I know nothing about it but find it very interesting.