Rogan got the vaccine and most likely has a medical prescription for Ivermectin, wouldn't be surprised if he's taking more than Ivermectin. Probably basing his treatment protocol on Pierre Kory's work.
* The Pierre Kory paper that started it all: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088823. Pierre is a front-line clinician that fights to figure out how to treat symptomatic patients, thus he has understandable biases.
* There is a pre-covid body of work documenting anti-viral properties of Ivermectin.
* There is a pre-covid body of work documenting anti-inflammatory properties of Ivermectin.
* There is a wide body of work documenting safety of Ivermectin in humans. The 2015 Nobel prize in medicine was awarded for the discovery of Ivermectin.
* There is some credible work that documents Ivermectin have some small effect in decreasing covid severity. See https://news.ycombinator.com/item?id=28351973 for some links. But there is other credible work that says it has no effect.
* There are some claims that introducing Ivermectin in a geographical area (some Indian states) correlates with a rapid decline of a covid epidemic outbreak. Alas, covid epidemic outbursts are spike shaped, so it is hard to say if Ivermectin had an effect or the outburst flamed out naturally.
* Some tropical countries where Ivermectin is routinely prescribed had low rates of sever covid outbreaks. This led some to believe Ivermectin has a hand in it. Alas, the age pyramid in those countries is leans young vs. age pyramid in the rest of the world leaning old. Given that covid is orders of magnitudes less dangerous for young people, this by itself explains disparities in covid severity outbreaks.
* There is a number of bulls**t websites that do 'meta-analyses' from low credibility poorly cited sources. Ignore.
* There is a ridiculously acrimonious Twitter fight between 'Ivermectin is a horse medicine that kills grandma' and 'Ivermectin is a covid-erasing magic wand' camps. I shudder at the hell a poor soul that wants to research 'there appears to be a weak signal in Ivermectin against covid, let's investigate deeper' must go through.
> TL;DR Vaccines vs. Ivermectin, in two pictures. Vaccines work, Ivermectin weakly moves the needle (maybe).
Since Ivermectin is mostly being hyped (and, often using veterinary formulations, abused) as a treatment rather than pre-diagnosis preventive, wouldn't a more appropriate contrast be Ivermectin vs. monoclonal antibody treatment?
I'm considering the wide class of 'medicines that reduce covid severity'.
To your point, I've heard reasonable Ivermectin proponents arguing that it works best as a preventive and/or started early after infection. To the infamous Youtube moment where somebody took preventive Ivermectin on camera.
Also, for context: https://www.healthsystemtracker.org/brief/covid-19-continues...