Depends on if you have someone to do it with and the scenery. I just drove from CA to NV, little bit of ID, and OR in a day and it was a great drive (just shy of 800mi). Lots of interesting scenery and places I've never seen. Broke it up into 2 days on the way back and slept at a nice campground.
I find that on trips, I'm a whole lot less interested in doing long drives than I used to be. I arranged a trip in the Western US for September and one of my decisions was that I'd basically limit the trip to one area of a state rather than zip around to multiple distanced places.
It's not so bad if you make sure to get good sleep the night before and start in the morning sometime, and perhaps take a long break somewhere in the middle.
That works for some people. I found that the seats in my P3D were decidedly mediocre at best (but I've gotten spoiled over the years by a lot of cars with Recaros). And AP does not drive either as smoothly as I do, nor as defensively as I do, which actually raises my blood pressure a bit. Cruise control with me steering is my most comfortable.
I'm getting old. The thought of driving 600+ miles in a single day sounds like hell.