> I think they made the Pfizer and Moderna vaccines extra strong (and double dose) because we were in the middle of a once-in-a-century pandemic.
Was looking into Pfizer’s effectiveness against the Indian variant since that seemed to be the most worrisome one out there and this was the vaccine I got.
What it boils down to:
1 shot + 3 weeks: 33% effective.
2 shots + 2 weeks: 88% effective.
Happy to have gotten both shots of Pfizer as overkill looks like exactly the right amount of kill. If I can get boosters down the line in the form of a patch, all the better really.
The Moderna shots seem to be far more overkill than even the Pfizer ones. 100 micrograms of mRNA vs 30 in the Pfizer. Both are probably more than necessary but they had one shot to nail it and they went all in on the first try. Likely related, myself and everybody I know had far worse side effects from the Moderna shots than the people I know who received the Pfizer ones.
The 3-4 week spacing was based on the first clinical results that came back. Now that we have data on longer spacings, it looks like waiting at least 3 months results in a stronger immune response. https://www.bmj.com/content/372/bmj.n18https://journals.plos.org/plosbiology/article?id=10.1371/jou... We had to rush the second shots to get immunity quickly, but for a later booster, the required dose might be a lot lower.
Was looking into Pfizer’s effectiveness against the Indian variant since that seemed to be the most worrisome one out there and this was the vaccine I got.
What it boils down to: 1 shot + 3 weeks: 33% effective. 2 shots + 2 weeks: 88% effective.
https://www.webmd.com/vaccines/covid-19-vaccine/news/2021052...
Happy to have gotten both shots of Pfizer as overkill looks like exactly the right amount of kill. If I can get boosters down the line in the form of a patch, all the better really.