> It seems like you can't blind the participants in this case? It should be obvious if you're getting the treatment because psilocybin is a hallucinogen, unless they're giving such a small dose that it reliably doesn't cause any hallucinations?
An active placebo can be used. For example: a high dose of methylphenidate and hallucinogen-naïve adults.[0]
An active placebo can be used. For example: a high dose of methylphenidate and hallucinogen-naïve adults.[0]
[0] Griffiths, et al. (2006) https://www.hopkinsmedicine.org/press_releases/2006/griffith...