I feel like more important and easier measures anyone can take to prevent RSI that doesn't involve learning a new keyboard layout are ergonomic: ensure you have a good chair/posture, use a wrist rest (these are debatable, but I couldn't type without one), and avoid taking your hands off the keyboard (don't use a mouse if possible).
I've been using QWERTY for decades now, and for years have used a ThinkPad keyboard with a TrackPoint instead of a mouse, use a mostly hotkey-driven workflow, and a wrist rest even on a laptop. Anecdotal, but I've rarely experienced strain and can type comfortably for hours.
I know QWERTY is demonstrably worse, but so far I haven't had the need to try another layout. The downsides of losing my current muscle memory, having to remap hotkeys and not being productive on other computers don't seem worth it to me.
My personal data on that is, I have been using all kinds of terrible desks, chairs, and keyboards before I got to a career point that I could buy nicer gear. I gotta credit Dvorak ahead of everything else.
I've been using QWERTY for decades now, and for years have used a ThinkPad keyboard with a TrackPoint instead of a mouse, use a mostly hotkey-driven workflow, and a wrist rest even on a laptop. Anecdotal, but I've rarely experienced strain and can type comfortably for hours.
I know QWERTY is demonstrably worse, but so far I haven't had the need to try another layout. The downsides of losing my current muscle memory, having to remap hotkeys and not being productive on other computers don't seem worth it to me.