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Yes just like SNRIs antidepressants so what is the difference? (stimulants also are dopamine reuptake inhibitors and low serotonine reuptake inhibitor)

And no it does not cause the release of any monoamine, when they are released they can stay longer in the brain before being garbage collected which virtually increase their density. It is an unknown whether delayed this garbage collection cycle accelerate ageing or other side effects.



The drugs you're talking about are classified NDRIs not SNRIs.

Amphetamine is a releasing agent too.

Different drugs have different receptor affinities. And the different metabolites do too.


I was incorrect in saying that stimulants are SNRIS, they are NDRIs as you say, however my point still stands. I don't understand the difference between e.g Adderall and Wellbutrin (which is an NDRI antidepressant)

Amphetamine is a releasing agent too good point but this additional aspect aside, dextroamphetamine should have the same antidepressant effect as Wellbutrin and I don't think that is the case, for an unknown reason.

Different drugs have different receptor affinities. Oh I thought Adderall was non-selective (affecting all receptors) but I might be wrong and that would be a possible explanation!

And the different metabolites do too. I don't know what this can imply.


Dextroamphetamine was prescribed for depression before other classes of drugs were invented. And bupropion is prescribed off label for ADHD. Amphetamine has much stronger dopaminergic effects though.

No 2 drugs are exactly alike. Their different metabolites also have their own effects.


No, sympathomimetics like amphetamines cause neurotransmitter release in addition to be reuptake inhibitors.


Doesn't induced neurotransmitter release lead to tolerance up to the point that the benefits 100% cancels out?




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