Adelaide to Darwin is a cakewalk in comparison. The Stuart Highway is fully paved, excellently maintained, and has roadhouses every 100 km or so. It's completely doable by a regular sedan or campervan, and if you run into any trouble, there's enough traffic that you won't be left in a lurch.
That said, there is still a whole lotta nothing along the way, and you still need to keep your eyes peeled or you'll run into wildlife or get flattened by a road train. It'll also be extra tedious if you can't alternate driving with somebody else.
Thanks yeah I think there's some interesting points(Flinders Range, Coober Peddy, Uluru) along the way there just not on or directly off the highway correct? I was unaware of a road train, is that where the train track do not have a proper crossing signals?
road trains are very long trucks https://en.wikipedia.org/wiki/Road_train#Australia going through the dusty red center (the dust from them often takes very long time to settle so no fun driving behind one :)).
the road to coober peddy, uluru etc should be maintained will enough today and provided you don't make shortcuts (or "go exploring" off the main road) but you still need to watch for large kangaroos, emus and dingos crossing. Dead or alive, they're no fun to crash into - although a road train will not stop for them (they probably couldn't even if they wanted to stop).
That said, there is still a whole lotta nothing along the way, and you still need to keep your eyes peeled or you'll run into wildlife or get flattened by a road train. It'll also be extra tedious if you can't alternate driving with somebody else.