that's something I don't understand. the Dev tools in Chrome and Firefox make it really easy to test through every resolution without problems. every UI change I make I view in all possible resolutions and its quite obvious of something breaks and I adjust accordingly.
If it takes too much time, you are probably doing something wrong like having hardcoded layouts for different resolutions instead of using reflow as much as possible.
Even with all reflow it's hard. Should I reduce a width a little bit more so that it become 3 columns instead of 2 on iPad vertical at risk of having some line wrapped? Things like that.