If your app is decent I would think using C#/.NET would increase your chances. Extra points for difficulty. Anybody can crank out a decent app in Lisp, but YC is investing more in the team than the app.
I can't tell if I'm joking either. Phil Greenspun does advocate the "great programmers can use any language" way. My life situation is such that I can't really afford to take a more difficult route just to show off.