You wouldn't be screwed if your business operates in Bitcoins, and your customers pay you in Bitcoins. If you take out a loan for 100 Bitcoins, you will still owe 100 Bitcoins, regardless of the USD exchange rate.
If you aren't dealing in USD, it doesn't matter how much value the USD loses.
Similarly, if you had debt denominated in USD, it wouldn't matter how much value the Zimbabwe Dollar or Weimar Republic Mark lost in hyperinflation. Your debt burden would be the same amount of USD. It just depends on your frame of reference.
The dollar has not reduced in value by a factor of six in the last few weeks. Nearly all of the change in the USD/BTC exchange rate is due to a reevaluation of the real value of bitcoins.
So even if you did all your business in them, it's likely prices would have fallen substantially in the last few weeks, and you would be screwed, per the grandparent.
That said, the source of BTC's volatility right now is precisely the fact that few people are doing business in them, and nearly all demand for them is speculative.
If you aren't dealing in USD, it doesn't matter how much value the USD loses.
Similarly, if you had debt denominated in USD, it wouldn't matter how much value the Zimbabwe Dollar or Weimar Republic Mark lost in hyperinflation. Your debt burden would be the same amount of USD. It just depends on your frame of reference.