A close friend's father uses Psilocybin to treat cluster headaches. He dealt with these debilitating headaches for a long time, basically unable to function as a normal human. This is in the US, and he is a former small business owner (retired), with money, and was able to see numerous specialists, attempted many treatments, all of which were unsuccessful. I'm not sure how he figured out that Psilocybin is an option.
Psilocybin is the only thing that relieves his cluster headaches for months at a time. I believe he doses 3ish grams of dried mushrooms, once a day for 2 days. I hope this gets more attention now that some states are decriminalizing Psilocybin. I suspect that other substituted tryptamines would be helpful as well, without needing to digest lots of mushroom fiber (which can be hard on the gut unless you fast for a period of time before consuming them). 4-HO-MET and 4-AcO-DMT comes to mind.
Psilocybin is the only thing that relieves his cluster headaches for months at a time. I believe he doses 3ish grams of dried mushrooms, once a day for 2 days. I hope this gets more attention now that some states are decriminalizing Psilocybin. I suspect that other substituted tryptamines would be helpful as well, without needing to digest lots of mushroom fiber (which can be hard on the gut unless you fast for a period of time before consuming them). 4-HO-MET and 4-AcO-DMT comes to mind.