Could be a fun game. For starters I'd move the most useless keys to the index finger home row positions, perhaps pipe and backtick. Then I'd invert the sense of shift, so you have to hold it to type anything lowercase. I'd take all the most common two-letter sequences and I'd move those letters under the weakest finger. So T H E O A R S and N replace the punctuation keys on the right side. This should make it a real hassle to type "the", especially considering that you'll be holding down shift, which should itself be somewhere hard to reach, such as where 6 usually goes.
