In this case, adverse effects from Bexarotene are virtually guaranteed, even at low doses. This study explored hypothyroidism in even low-dose Bexarotene and found 61 out of 66 patients exhibited hypothyroidism: https://pubmed.ncbi.nlm.nih.gov/30903705/
Bexarotene also significantly elevates cholesterol markers and blood lipids, which would accelerate heart disease and shorten lifespan.
The researchers aren’t simply dismissing drugs at the first sign of side effects. We have many drugs on the market with significant contraindications due to adverse side effects in specific populations, and doctors are generally well-informed about testing for these conditions and selecting only suitable drug candidates.
Bexarotene also significantly elevates cholesterol markers and blood lipids, which would accelerate heart disease and shorten lifespan.
The researchers aren’t simply dismissing drugs at the first sign of side effects. We have many drugs on the market with significant contraindications due to adverse side effects in specific populations, and doctors are generally well-informed about testing for these conditions and selecting only suitable drug candidates.