I can't verify this at the moment, but I'm pretty sure that you can assign the right and middle click actions on a three button mouse to do Cmd- and ctrl- clicks, so this is a nonissue for those of us with a standard mouse.
I'm thinking more about the macbook pros that I see lots of people with. Another pet peeve with apple laptops is that the physical click is only at the bottom of the trackpad - why not the top? I have large hands and it's really not anywhere near the resting place for my fingers, especially if I'm typing.
