Since you have a signal processing background... what would be super cool is if there was a tool that could analyze all the chords in a song file (e.g., mp3) and magically create a Rocksmith/Guitar Hero style "racetrack" for practicing. DLC can get expensive quite fast, and songs you want to play may not always be available without modding/hacks/cracks, etc.
I'll keep this in mind! It is a tremendously more difficult problem though due to all the other instruments (including voice), distortion, etc. in real music tracks compared to a clean guitar signal. This is when you would have to break out the neural networks. Machine learning happens to be my day job so it's not impossible! But for now I'm keeping my target scope small :)