For a static site that one can drag-and-drop to, I'd just use S3's new 'website' bucket configuration with CyberDuck as the S3 client (folder sync or drag-and-drop files).
Oh, I wasn't going on about that specific client (I am also really happy with Transmit) just about the thought that people need to be warned about paid software.
I'm currently building a site generator for photoblogs hosting directly on S3. Seems like good performance, cheap hosting and no more worries about Wordpress
It's always being hacked/targeted, requires constant updating, needs plugins for some functionality, and these may throw a hissy fit when you perform one of the many essential updates. Basically it's a general tool and a victim of its own success.
I'm going to built something that fits my exact needs and produces a static site hosted on S3.