On: To develop a coronavirus vaccine, synthetic biologists try to outdo nature

[allovernow]

AFAIK the closest they got to working vaccines for SARS and MERS cause lung damage from autoimmune response in each tested animal model.

The issue with these viruses is that they have a property known as Antibody Dependent Enhancement (ADE). Where normally neutralizing antibodies instead facilitate entry into your cells.

[selectodude → allovernow]

That was a big issue early on, but I think they were able to work past it before funding and interest dried up.

[vorticalbox → selectodude]

Didn't the SARS vaccine also cause the host to die when reinfected?

[selectodude → vorticalbox]

Early versions were causing even more extreme cytokine storms than the SARS virus did without the vaccine.

This shit is trial and error with some difficult to handle results when things are still in development. Which is why the idea that we'll have a safe and effective vaccine within the year is a complete pipe dream.