Python rocks, but I know at least a few of you out there are using the Microsoft stack... :)
Most startups founders I've talked to use Python and Amazon Web Services for scalability. Until Microsoft reveals their cloud computing solution, it seems there aren't too many choices for the Microsoft stack hosted scaling solutions, besides Mosso. I've heard Amazon can be used with a .NET app, as long as you are not running SQL Server on the back-end. Is anyone using MS SQL Server Express as the database engine for their startup? How do people here using the Microsoft stack approach scalability issues?
Here's the typical example: http://highscalability.com/plentyoffish-architecture
In my experience, virtuals/slices do not scale well for app servers in the MSFT stack.