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An interesting alternative approach for instrument sound separation is to use a fused audio + video model. So, given that you also have video of the instruments being played, you can perform this separation with higher fidelity.

I was fascinated by the work done by “The Sound of Pixels” project at MIT.

http://sound-of-pixels.csail.mit.edu/




That’s quite clever but not really practical : instruments heard in most music produced today aren’t "played" by humans.




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