By trial and error since I was diagnosed 11 years ago, I have settled to take them - except for resveratrol and berberine - at bedtime. The effect is clearly noticeable. I thought it was because my body needed them most while recovering from everyday activities, but as usual, things get more complicated as we gain knowledge.
Anyway, an interesting read and another opportunity to further improve my health.
My rationale here is to midly uncouple complex I of the electron transport chain to induce mitochondrial biogenesis of my wild type mitochondria.
All of this would be much easier with, and the correct contribution of tech would be, integrated continuous telemetry from smart sensors and systems. That data would also be a privacy nightmare and should be something that the patient can read and choose to share or not.