On: Total cholesterol and all-cause mortality – a study among 13M adults

[carbocation]

> "Sure, but I think the whole of the field has rabbit-holed on lipids for too long, ignoring actual causal factors."

LDL cholesterol is by far the best established causal risk factor for coronary artery disease.

> "Check the evalocumab trial I posted, ACM was actually slightly worse in the PCSK9 side of the trial."

All cause mortality was significantly lower in Odyssey: https://www.nejm.org/doi/full/10.1056/NEJMoa1801174

[virtuallynathan → carbocation]

> LDL cholesterol is by far the best established causal risk factor for coronary artery disease.

Is it causal, or is it a risk factor? I'd say at best it is "necessary but not sufficient". CVD risk calculators don't even take LDL-C into account, that's how good of a marker it is.