Yup. If I have about 40 tabs open in Chrome, especially with some Flash videos or JS-heavy sites, Chrome can easily chew up a a gig and a half of memory and slow everything to a crawl. There is no magic bullet.
Bumping my memory up to 8GB ($130 from crucial) helped a lot though. No more paging issues for now even when running photoshop, firefox, safari, chrome, zend studio/rubymine/eclipse (yes, I use vim too, but it uses practically no memory)
esp if flash is involved chrome can get really mean... not saying other browsers are better.
besides that chrome is insanely fast on osx. i compared it with win and its a bit snappier on osx. for whatever internal reasons.
Bumping my memory up to 8GB ($130 from crucial) helped a lot though. No more paging issues for now even when running photoshop, firefox, safari, chrome, zend studio/rubymine/eclipse (yes, I use vim too, but it uses practically no memory)