I turn Spectre/Meltdown protection off (download InSpectre if you run Windows). My Haswell machine gets a noticeable boost (e.g. about 5% increase in Intel XTU benchmark), but newer architectures are less negatively affected by the patches so you may not find the effort/risk to be worth it.
I am amused at the threat model that might be concerned, on one hand, with extremely complex and difficult speculation attacks, and on the other hand permits downloading random Windows apps and running them at the highest possible privilege level. Clearly the public is of two minds.