On: Ketamine: From Party Drug to Prescription Medicine

[mveety]

Esketamine doesn’t have the same activity as racemic or Arketamine (S- hits some of the dopamine receptors harder and doesn’t bind with the sigma ones iirc). Patients seem to find esketamine more pleasant because of this and it’s eliminated faster than R- so patients can (probably) get back to normal faster.

(Edit: had my right from left mixed up. It’s been a while)

[dawhizkid → mveety]

So maybe it makes you a little less groggy but at 300x the price? Don't think anyone can say that justifies the price multiple.

[xkcd-sucks → mveety]

Now r-ket can be developed as a patentable improvement over the state of the art :)