My mentor once told me, "you can have it all, just not all at the same time."
Time and time again I forget and try to do it all, and I end up frustrating myself. I know this, but I often forget: If I want to succeed at the things that are important to me in my life (such as building a successful startup), there will be areas in my life that I will have to be ok with getting a failing grade in. (e.g. relationships will suffer, etc.)
It's one thing to try and fail (negative "ROI"), it's another to knowingly accept and say, "ok, I'm going to get a C- in certain areas so I'm not going to invest too much of my finite resources in this area (non-negative ROI)."
Would successful entrepreneurs share with us here what they had to give up?
Personally, I find it hard to keep up with my relationships. If I know that others went through the same, it would make me feel a lot better that it's not just me. (Or if it is possible to have it all, please do tell!)
The primary thing that you'll always give up while running a business is free-time. Free-time doesn't exist. Vacation? Forget it. Television? Aside from your weekly sports games or whatever you have, there's little reason to be watching the TV.
I think "normalcy" is the greatest thing you give up. However I think normal people are always wondering what they're going to do with their life in the future or simply wasting it away in the now. Entrepreneurs on the other hand are creating the future so I'd rather be there than spending my time mastering the latest World Of Warcraft series (sorry to WOW players).