That is a potential approach. However, the things that cause cancer are typically dysregulation of self proteins. These are usually things that stop and start cell growth and replication. In these cases, it is not totally clear in these cases what can cause recognition (perhaps overabundance causes higher presentation on the outside of cells and maybe enhanced recognition by some T cells can cause killing--I am speculating as I'm a couple years out of date on the literature).
Other cancers there may be a mutation in one of these genes that makes it more or less effective and lead to cell cycle deregulation. Those are good targets for T cell killing.
In any case, it is probably a more effective approach in cases where we understand potential epitope targets to directly expand T cells that can do the killing rather than having some intermediary in the mix.
Other cancers there may be a mutation in one of these genes that makes it more or less effective and lead to cell cycle deregulation. Those are good targets for T cell killing.
In any case, it is probably a more effective approach in cases where we understand potential epitope targets to directly expand T cells that can do the killing rather than having some intermediary in the mix.